Genetics of Healthy Ageing (GEHA)
The aim of the Integrated Project GEHA is to identify genes involved in healthy aging and longevity, which allow individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. Data consist of more than 2500 sibpairs aged 90+, and younger controls. Altogether 25 research groups from 11 European countries and China participate in the project. GEHA is coordinated by Professor Claudio Franceschi from the University of Bologna. The funding period from the EU 6 FP has expired but analysis and reporting continue. GEHA homepage: http://www.geha.unibo.it/page_display.asp?pid=13
Funding
EU FP 6 (until 2009)
Research group in Finland
Principal Investigator
Professor Antti Hervonen, antti.hervonen (at) uta.fi, School of Health Sciences, University of Tampere
Other Senior researchers
Professor Mikko Hurme, mikko.a.hurme (at) uta.fi, School of Medicine, University of Tampere
Professor Marja Jylhä, marja.jylha(at)uta.fi, School of Health Sciences, University of Tampere
Professor Kari Majamaa, kari.majamaa at oulu.fi, Institute of Clinical Medicine, University of Oulu
Publications
Franceschi C, Bezrukov V, Blanché H, Bolund L, Christensen K, de Benedictis G, Deiana L, Gonos E, Hervonen A, Yang H, Jeune B, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Peltonen L, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Stazi MA, Toussaint O, Vaupel JW. Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).Ann N Y Acad Sci. 2007 Apr;1100:21-45. Review.
Rose G, Romeo G, Dato S, Crocco P, Bruni AC, Hervonen A, Majamaa K, Sevini F, Franceschi C, Passarino G; GEnetics of Healthy Ageing Project Consortium. Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study.PLoS One. 2010 Oct 14;5(10):e13395.
Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium. Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. Exp Gerontol. 2011 Nov;46(11):934-45. Epub 2011 Aug 16. PubMed PMID: 21871552.